Based on natural biodiversity and the company’s own BioArchive, BRAIN focuses on three product categories for highly differing applications – bioactive natural compounds, customized enzymes and high-performance microorganisms.
The huge diversity of microorganisms and new microbial processes and products is at the root of the biotechnology success story. Together with forward-looking partners from the chemical, pharmaceutical and cosmetics industries and from the food, life science and bioenergy sectors, BRAIN is working to establish a sustainable, knowledge-based bioeconomy, which will transform entire industries through innovative biotechnology methods.
The BRAIN Group’s proprietary BioArchive offers access to an immense variety of new biological solutions for sustainable industrial processes and ingredients. The BioArchive encompasses more than 53,000 comprehensively characterized cultivable microorganisms, more than 50,000 characterized natural compounds and fractions consisting of edible plant material, a large number of highly specialized metagenome libraries as well as many new enzyme libraries and complete metabolic paths comprising previously uncultivable organisms. The company is continuously expanding this unique, dynamic “toolbox of nature”.
BRAIN has a broadly protected high-tech portfolio that ensures the targeted discovery, decoding and further development of natural resources and their sustainable availability, and offers extensive know-how and high-end technology platforms to meet new scientific and technological challenges. The company harnesses state-of-the-art technology and specialist expertise such as high-throughput sequencing, metagenome and big data analysis, protein engineering, genome editing, digital 3D modeling and test simulation, cell-based test systems, high-speed screening and AI-assisted process optimization.
BRAIN focuses on three product categories which are driven by respective technology units: bioactive natural compounds, customized enzymes and high-performance microorganisms.
Bioactive natural compounds
BRAIN identifies and develops bioactive natural compounds, so-called BioActives, for product developments in the food, animal feed, skin care, cosmetics and chemical industries. Its focus is on the optimized biological effect of natural compounds and the improvement of formulations for customized applications. The product range includes sugar substitutes and taste modulators for healthier nutrition as well as natural-based active ingredients for cosmetics, BioActives for food preservation as well as for the stabilization of paints, lacquers, and various household products.
BRAIN identifies and develops new and optimized enzymes and biocatalysts that meet complex process and application requirements for very varied product classes, and as starter cultures enable innovative technical production processes to be established. These include enzymes for the production of food and beverages, wound care preparations or lubricants as well as for starch and bioethanol production. Research work in the new product development area focuses on serving high-margin markets for special enzymes.
BRAIN identifies and develops high-performance microorganisms as functional biomass for optimized industrial production processes. They serve as so-called BioSubstitutes to establish bioprocesses in chemical processes or to produce bioactive natural compounds and enzymes for specialty markets. Application areas also include the recycling of the climate gas CO2 as an industrial raw material for bioplastics, as well as urban and green mining for the extraction of precious metals and rare earth metals from waste flows and ores.
Hypotonic stress response of human keratinocytes involves LRRC8A as component of volume‐regulated anion channels
Trothe J, Ritzmann D, Lang V, et al. Hypotonic stress response of human keratinocytes involves LRRC8A as component of volume‐regulated anion channels. Exp Dermatol. 2018;27:1352–1360. https://doi.org/10.1111/exd.13789
A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium‐activated chloride secretion in human sweat gland epithelial cells
Ertongur-Fauth, T., Hochheimer, A., Buescher, J. M., Rapprich, S. and Krohn, M. (2014), A novel TMEM16A splice variant lacking the dimerization domain contributes to calcium-activated chloride secretion in human sweat gland epithelial cells. Exp Dermatol, 23: 825–831. https://doi.org/10.1111/exd.12543
Marker-free genome editing in Ustilago trichophora with the CRISPR-Cas9 technology
Simon Huck, Josephine Bock, Jörg Girardello, Marc Gauert & Ümit Pul (2018) Marker-free genome editing in Ustilago trichophora with the CRISPR-Cas9 technology, RNA Biology, DOI: 10.1080/15476286.2018.1493329
Using gas mixtures of CO, CO2 and H2 as microbial substrates
Ralf Takors, Michael Kopf, Joerg Mampel, Wilfried Bluemke, Bastian Blombach, Bernhard Eikmanns, Frank R. Bengelsdorf, Dirk Weuster‐Botz, Peter Dürre
First published: 14 May 2018, https://doi.org/10.1111/1751-7915.13270